Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata

Authors

Anthony R. Carroll
Sylvia Urban
Jasmine Lamb, University of Notre Dame AustraliaFollow
Roger Moni
Gordon P. Guymer
Paul I. Forster
Ronald J. Quinn

Publication Details

Carroll, A. R., Urban, S., Lamb, J., Moni, R., Guymer, G. P., Forster, P. I., et al. (2008). Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. Journal of Natural Products, 71(5), 881–883. doi:10.1021/np0706567

Abstract

High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC₅₀ values of 23 and 19 μM, respectively.

Keywords

peer-reviewed