ompassionate access to virus-specific T cells for adoptive immunotherapy over 15 years
Publication Details
Neller, M.,
Ambalathingal, G.,
Hamad, N.,
Sasadeusz, J.,
Pearson, R.,
Holmes-Liew, C.,
Singhal, D.,
Ng, W. Y.,
Sharplin, K.,
Moore, A.,
Deambrosis, D.,
Soosay-Raj, T.,
McNaughton, P.,
Whyte, M.,
Fraser, C.,
Grigg, A.,
Kliman, D.,
Bajel, A.,
Cummins, K.,
Dowling, M.,
Yeoh, Z.,
Harrison, S.,
Khot, A.,
&
Tan, S.
(2024).
ompassionate access to virus-specific T cells for adoptive immunotherapy over 15 years.
Nature Communications, 15, 10339.
Abstract
Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with “off-the-shelf” allogeneic T cells directed to a combination of Epstein–Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration’s Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder. Adoptive immunotherapy is well tolerated with few adverse effects. Importantly, 46/71 (65%) patients show definitive clinical improvement including reduction in viral load, clinical symptoms and complete resolution of end-organ disease. In addition, seven high-risk patients remain disease free. Based on this long-term encouraging clinical experience, we propose that a dedicated nationally funded centre for anti-viral cellular therapies should be considered to provide T cell therapies for critically ill patients for compassionate use.
Keywords
immunotherapy, outcomes research, t cells, viral infection
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