Predictors of mortality post-gastrostomy in motor neuron disease patients
Publication Details
Yang, J.,
Zhao, Y.,
Soares, M.,
Needham, M.,
Begley, A.,
&
Calton, E.
(2024).
Predictors of mortality post-gastrostomy in motor neuron disease patients.
Muscle and Nerve,.
Abstract
Introduction/Aims: Motor neuron disease (MND) is a progressive neurodegenerative condition with a limited life expectancy. There is very little data on mortality and it sassociated factors beyond 30 days following gastrostomy. We explored the demo-graphic, clinical, and nutritional predictors for early mortality at 30, 90, and 180 days following gastrostomy in these patients.
Methods: This was a retrospective study involving 94 MND patients in Western Australia who underwent gastrostomy between 2015 and 2021. Patients were divided into two groups based on mortality at 30, 90, and 180 days post-gastrostomy. T-test (or Mann–Whitney), chi-square test and Fisher's exact test were used for detecting between-group differences in various factors. Multivariable logistic regression was used to identify factors associated with post-gastrostomy mortality at90 and 180 days.
Results: No mortality was attributable to gastrostomy-related complications. Lowerforced vital capacity (FVC) (p = .039) and greater weight loss (%) (p = .022) fromdiagnosis to gastrostomy were observed in those who died within 30 days post-gastrostomy. Older age (p = .022), male sex (p = .041), lower FVC (p = .04), requiringbut not tolerating noninvasive ventilation (p = .035), and greater weight loss (%)(p = .012) were independent predictors of 90-day post-gastrostomy mortality. How-ever, only older age (p = .01) and greater weight loss (p = .009) were predictors ofmortality at 180 days post-gastrostomy
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