Long-term outcomes of corticosteroid graft versus host disease prophylaxis in peripheral blood allogeneic haemopoietic stem cell transplant: A comparative cohort analysis
Publication Details
Blennerhassett, R.,
Othman, J.,
Biscoe, A.,
Kliman, D.,
Mills, G.,
Blyth, E.,
Micklethwaite, K.,
Kwan, J.,
Bilmon, I.,
Bhattacharyya, A.,
Panicker, S.,
Fay, K.,
Milliken, S.,
Ma, D.,
Hamad, N.,
Stevenson, W.,
Arthur, C.,
Moore, J.,
Greenwood, M.,
Gottlieb, D.,
&
Kerridge, I.
(2023).
Long-term outcomes of corticosteroid graft versus host disease prophylaxis in peripheral blood allogeneic haemopoietic stem cell transplant: A comparative cohort analysis.
Internal Medicine Journal,.
Abstract
Background: Corticosteroids (CSs) have previously been incorporated into graft versus host disease (GVHD) prophylaxis regimens for bone marrow (BM) and haemopoietic stem cell transplant (HSCT).
Aims: To assess the impact of prophylactic CS in HSCT using peripheral blood (PB) stem cells. Methods: Patients were identified from three HSCT centres receiving a first PB-HSCT between January 2011 and December 2015 from a fully human leukocyte antigen (HLA)-matched sibling or unrelated donor for acute myeloid leukaemia or acute lymphoblastic leukaemia. To enable meaningful comparison, patients were divided into two cohorts.
Results: Cohort 1 included only myeloablative-matched sibling HSCT, where the only variation in GVHD prophylaxis was the addition of CS. In these 48 patients, there were no differences in GVHD, relapse, non-relapse mortality, overall survival or GVHDrelapse-free-survival (GRFS) at 4 years after transplant. Cohort 2 included the remaining HSCT recipients, where one group received CS-prophylaxis and the non-CS group received an antimetabolite, ciclosporin and anti-T-lymphocyte globulin. In these 147 patients, those receiving CS-prophylaxis experienced higher rates of chronic GVHD (71% vs 18.1%, P < 0.001) and lower rates of relapse (14.9% vs 33.9%, P = 0.02). Those receiving CS-prophylaxis had a lower 4-year GRFS (15.7% vs 40.3%, P = 0.002).
Conclusions: There does not appear to be a role for adding CS to standard GVHD prophylaxis regimens in PB-HSCT.
Keywords
haemopoietic stem cell transplant, graft versus host disease, corticosteroids
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