Moderate aortic valve stenosis is associated with increased mortality rate and lifetime loss: Systematic review and meta-analysis of reconstructed time-to-event data of 409 680 patients
Publication Details
Jacquemyn, X.,
Storm, J.,
Strange, G.,
Playford, D.,
Stewart, S.,
Kutty, S.,
Bhatt, D.,
Bleiziffer, S.,
Grubb, K.,
Pellikka, P.,
Clavel, M.,
Pibarot, P.,
Mentias, A.,
Serna-Gallegos, D.,
Sa, M.,
&
Sultan, I.
(2024).
Moderate aortic valve stenosis is associated with increased mortality rate and lifetime loss: Systematic review and meta-analysis of reconstructed time-to-event data of 409 680 patients.
Journal of the American Heart Association, 13 (9).
Abstract
Background: The mortality risk attributable to moderate aortic stenosis (AS) remains incompletely characterized and has historically been underestimated. We aim to evaluate the association between moderate AS and all-cause death, comparing it with no/mild AS (in a general referral population and in patients with heart failure with reduced ejection fraction).
Methods and results: A systematic review and pooled meta-analysis of Kaplan–Meier-derived reconstructed time-to-event data of studies published by June 2023 was conducted to evaluate survival outcomes among patients with moderate AS in comparison with individuals with no/mild AS. Ten studies were included, encompassing a total of 409680 patients (11527 with moderate AS and 398153 with no/mild AS). In the overall population, the 15-year overall survival rate was 23.3% (95% CI, 19.1%–28.3%) in patients with moderate AS and 58.9% (95% CI, 58.1%–59.7%) in patients with no/mild aortic stenosis (hazard ratio [HR], 2.55 [95% CI, 2.46–2.64]; P
Conclusions: Moderate AS was associated with higher risk of death and lifetime loss compared with patients with no/mild AS.
Keywords
aortic valve, aortic valve disease, aortic valve stenosis, heart valve diseases, meta-analysis
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