Exercise-induced responses in matrix metalloproteinases and osteopontin are not moderated by exercise format in males with overweight or obesity

Authors

Aaron Raman
Jeramiah J. Peiffer
Gerard Hoyne, The University of Notre Dame AustraliaFollow
Nathan G. Lawler
Andrew Currie
Timothy J. Fairchild

Publication Details

Raman, A., Peiffer, J. J., Hoyne, G., Lawler, N. G., Currie, A., & Fairchild, T. J. (2022). Exercise-induced responses in matrix metalloproteinases and osteopontin are not moderated by exercise format in males with overweight or obesity. European Journal of Applied Physiology, Early View (Online First).

Abstract

Purpose: Matrix metalloproteinase-2 (MMP-2) and -3 (MMP-3), and osteopontin (OPN) are associated with adipose-tissue expansion and development of metabolic disease. The purpose of the current study was to assess the circulating concentration of these markers, along with adiponectin and glucose concentrations, in response to acute exercise in individuals with overweight or obesity.

Methods: Fourteen sedentary males with overweight or obesity (29.0±3.1 kg/m² ) completed two separate, 3-day trials in randomised and counterbalanced order. An oral glucose tolerance test (OGTT) was performed on each day of the trial. Day two of each trial consisted of a single 30 min workload-matched bout of either high-intensity interval exercise (HIIE; alternating 100% and 50% of peak pulmonary oxygen uptake, . VO2_peak) or continuous moderate intensity (CME; 60% . VO2_peak) cycling completed 1 h prior to the OGTT. Glucose and physical activity were continuously monitored, while MMP-2, MMP-3, OPN and adiponectin were measured pre-, 0 h post-, 1 h post- and 25 h post-exercise.

Results: Exercise transiently increased MMP-3 and decreased OPN (both p<0.01), but not MMP-2 or adiponectin. There were no diferences in the response of infammatory markers to the diferent exercise formats. Exercise increased mean daily glucose concentration and area under the glucose curve during the OGTT on Day 2 and Day 3 (main efect of time; p<0.05).

Conclusion: Acute cycling exercise decreased OPN, which is consistent with longer term improvements in cardiometabolic health and increased MMP-3, which is consistent with its role in tissue remodelling. Interestingly, exercise performed prior to the morning OGTT augmented the glucose concentrations in males.

Trial registration: ACTRN12613001086752.

Keywords

obesity, cardiovascular disease, glucose regulation, interval training, high intensity

Link to Publisher Version (URL)

10.1007/s00421-023-05133-3