The role of the innate and adaptive immunity in exercise induced muscle damage and repair

Authors

B Jones, The University of Notre Dame AustraliaFollow
G Hoyne, The University of Notre Dame AustraliaFollow

Publication Details

Jones, B., & Hoyne, G. (2017). The role of the innate and adaptive immunity in exercise induced muscle damage and repair. Journal of Clinical and Cellular Immunology, 8 (1).

Abstract

The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory T cells. In this review we examine the process of exercise induced muscle damage to provide comparisons of how this may follow a similar coordinated response as that mediated by toxin induced damage.

Keywords

exercise, muscle damage, tissue repair, innate immunity, cytokines

Link to Publisher Version (URL)

https://www.omicsonline.org/peer-reviewed/the-role-of-the-innate-and-adaptive-immunity-in-exercise-induced-musclerndamage-and-repair-84073.html