Characteristics of the arthropathy described in hereditary haemochromatosis
Carroll, G. J., Breidahl, W. H., & Olynyk, J. K. (2011). Characteristics of the arthropathy described in hereditary haemochromatosis. Arthritis Care and Research, Online First. doi:10.1002/acr.20501
Hereditary Haemochromatosis is a common inherited disorder, which primarily affects populations of northern European origin. Individuals homozygous for the C282Y mutation in the HFE gene product have up to a 30 percent chance of developing significant disease as a result of iron overload. Arthropathy is arguably the most disabling complication of iron overload in this disorder. Here we review the clinical and pathophysiological aspects of arthropathy in Hereditary Haemochromatosis.