Increase in circadian variation after continuous-flow ventricular assist device implantation
Slaughter, M. S., Ising, M. S., Tamez, D., O'Driscoll, G., Voskoboynikov, N., Bartoli, C. R., (2010). Increase in circadian variation after continuous-flow ventricular assist device implantation. Journal of Heart and Lung Transplantation, 29(6), 695-697. doi:10.1016/j.healun.2009.12.006
The circadian rhythm of varying blood pressure and heart rate is attenuated or absent in patients with severe heart failure. In 28 patients supported by a left ventricular assist device (LVAD) for at least 30 days, a restoration of the circadian rhythm was demonstrated by a consistent nocturnal decrease, and then increase, of the LVAD flow while at a constant LVAD speed. The return of the circadian rhythm has implications for cardiac recovery, and the observation indicates that the continuous-flow LVAD has an intrinsic automatic response to physiologic demands.
peer-reviewed, heart failure, circadian rhythm, ventricular assist devices, diurnal variation