Short-course total lymphoid irradiation for refractory cardiac transplantation rejection
Lim, T. S., O’Driscoll, G., Freund, J., Peterson, V., Hayes, H., & Heywood, J. (2007). Short-course total lymphoid irradiation for refractory cardiac transplantation rejection. Journal of Heart and Lung Transplantation, 26(12), 1249-1254. doi: 10.1016/j.healun.2007.09.002
Background: Total lymphoid irradiation (TLI) has been used as an effective therapy for refractory allograft cardiac transplantation rejection. In this study we assessed our short-course TLI regimen for treatment of this condition.
Methods: A short course of TLI (4.5 Gy in 4 fractions) was given to 6 patients with recalcitrant allograft cardiac transplant rejection at the Royal Perth Hospital.
Results: Treatment compliance was excellent with most patients having no acute toxicity. With a median follow-up of 25 months, 83% of patients remain alive and disease-free.
Conclusions: To date, no convincing evidence of radiation-related late effects have been documented with TLI. Nonetheless, larger scale trials are required for validation before this approach can be widely incorporated into the current transplantation (Tx) rejection regimen.