How should we conduct and interpret phase III clinical trials in palliative care?
Abernethy, A. P., Clark, K., & Currow, D. C. (2010). How should we conduct and interpret phase III clinical trials in palliative care? Journal of Pain and Symptom Management, 39(1), e6-8. doi: 10.1016/j.jpainsymman.2009.08.003
The article by Wildiers et al.1 raises some challenges in terms of ethical approaches to phase III end-of-life studies and their interpretation. Although the authors should be commended for undertaking a large, multisite, randomized, controlled trial in palliative care, there are fundamental questions that do need to be addressed before the first steps can be taken to adopt the study's findings into practice.