Article Title

The effect of season on cytokine expression in multiple sclerosis and healthy subjects

Abstract

We measured the levels of IFNγ, TNFα, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFα, and a winter excess of IFNγ. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no seasonal effect.

Keywords

peer-reviewed

 

Link to Publisher Version (DOI)

http://doi.org/10.1016/j.jneuroim.2007.06.012